When playing Truck Simulator PRO 2016, players can drive different kinds of trucks through varied locations in the US. These trips will be difficult and adventurous— particularly when traveling to far-away places. The game begins by selecting a starting location. Afterwards, you can select between two locations, each containing a number of trailers. Key functions are displayed on the left side of the screen for adjacent observation by players. You maneuver your truck in third person from any angle, and can reconfigure it as desired. Additionally, helpful buttons flank the controls for your car. You can toggle the map display, see your damage level and vehicle color while driving and view a breakdown of your vehicle's features from the dashboard. You can also choose a parking spot before reaching it, as this feature is available from the dashboard.

After selecting the location of Truck Simulator PRO 2016, a car will appear there. Players can then access a garage to modify their vehicle. A red button will give players coins with a specific amount attached, and a green button will give players access to the shipping process. Players can freely choose locations and then the shipping process will start in whichever location they selected. When you first meet the trailer, a connecting button will appear next to a black information panel on the left. When your cursor is over this button, your connection is complete. In order to complete this mission, you need to take note of the marking at that exact moment. At the same time, you must steer clear of other vehicles and bypass any upcoming roads as much as possible so that the trailer remains undamaged. When playing a driving simulation game, it's important to understand that the player's road is completely accurate. They need time to adjust to these roads before they can drive without focusing on their surroundings. Additionally, new drivers need to use more caution when compensating for turns. When you reach your destination, you’ll disconnect your trailer and receive a reduction in the cost. But you won’t get the full cost; instead, you’ll receive only a portion of the trailer damage and any other factors that don’t conform to your journey.

When working in Truck Simulator PRO 2016, the garage button helps you adjust the vehicle with many different elements. First, you earn money to buy a new truck. Each model has its own specific traits that you can adjust. In order to fully upgrade your vehicle, you must consider additional factors after purchasing it. For instance, you can use public transportation or stays in a hotel to assist with this process.