In Lost in Harmony, the player helps Kaito navigate through locations and face vehicle and obstacle challenges. The girl he serves is the game's primary protagonist; she uses a skateboard to navigate. Kaito needs the player's help when many vehicles appear throughout his journey. Additionally, the player must help Kaito overcome any obstacles that arise during this process. This means the player must find solutions that help Kaito overcome these challenges and complete the level successfully. This game blends endless running and rhythmic gameplay that pulls in players. At the start of the game, Kaito doesn’t move forward; he circles players counterclockwise. Players need to watch the vehicles moving behind Kaito at the same time they need to watch him.

When the Lost in Harmony level begins, Kaito automatically moves across the road. Additionally, small lights fall from the sky as he moves. Players need to fully collect these elements because they impact how many points players earn in the game. At the same time, when this picking phase is complete, new game mechanics open that involve rhythm gameplay with four empty squares that form a four-pointed star.

Inside Lost in Harmony, you can observe various beautiful environments with astounding designs. Each location exhibits different characteristics but shares a common trait: lights the player can pick up and vehicles that perpetually attempt to attack Kaito. Additionally, the game's difficulty level increases over time and grows more daunting for players. Gamers can share their edited levels with other players through the game's built-in sharing feature. Different players can come across different levels of difficulty in the same game, with some being much more challenging than others. This feature makes it easy for gamers to find a level they can complete and enjoy the accompanying soundtrack. Kaito travels through many difficult locations along his adventure. The game's gameplay and rhythm combine to endlessly run to different positions. They constantly shift positions multiple times at each game level. Kaito moves toward the player and consiguses dodging behind him while picking up lights. You need to correctly touch the stars during the rhythm section after running to infinity. Every location the game traverses has a unique artistic style and significant challenge. Players also pay attention to the musical scores featured in each location. In a game's edit feature, players can create new levels or challenge existing ones by other players.