The Acid Girls' Escape project mostly uses pretty girls as the focus of the projects. As such, players must help them escape by completing all the puzzles and finding the correct paths through each level. No hints or tutorials are present in the game; instead, this adds to the difficulty by removing any point-and-click assistance. It also intensifies gameplay by providing a completely different form of assistance than a typical point-and-click game. This is because players need to find each girl's objectives scattered on the road— some even hidden in cars or buildings — and help them escape. In order to solve the puzzles, players must find a single way out that doesn’t result in death. The game’s creator designed the puzzles with one specific method, which heightens the difficulty after each attempt. As more hints are revealed, the puzzles can be redesigned to become more challenging. Once solved, players can finally overcome all deaths and new puzzles will be revealed to them.

Players collect unique death animations and puzzles for each girl by solving the game's puzzles. The puzzles require the player to cause death and dismemberment, which results in entertaining but bloody deaths. These death animations are automatically recorded in the log, allowing players to review all their data and avoid repeating the puzzle a second time. Although players must trigger each puzzle multiple times, it's still better than re-triggering the puzzle accidentally. This guarantees each girl will have a unique death animation that combines with their puzzle. As the player progresses through new levels, their death animations become more challenging and difficult to trigger. This serves to inspire the player, and violent moments are added to each achievement so players can preview solutions or find out how to trigger each mechanic. Additional mysteries and stories about each female character are also added alongside each puzzle. This provides an even more impressive experience for the player.

In every point-and-click game, like Acid Girls' Escape, finding important items must be done by interacting with everything in the environment. Items can be found anywhere and some can be used to access even harder challenges if used carefully. These include saving the girls. Players can also use a save or load function to replay each challenge and come up with new ways to solve the puzzle.

The Acid Girls' Escape plot requires the player to unlock each girl's endings through multiple puzzles and deaths. This is different from unlocking death animations; instead, the player must successfully pass a puzzle with the fewest deaths. This proves that each girl's personality and emotions differ, which players can discover with more discoveries and experiences when they rescue all girls with tragic fates. The storyline of Acid Girls’ Escape revolves around puzzle-based challenges, as well as the horror of each death. Players unlock any achievement or performance by solving these puzzles, which are coupled with retro-themed graphics. These new colors and ideas make everything more dramatic and attractive, drawing in a new audience. ———